In some cases, dietary changes are
not enough and cholesterol lowering medication is required. Statins
are the most widely used cholesterol-lowering drugs currently
available. However, because statins and plant stanols have
different mechanism of action, the cholesterol lowering
effects of statins and Plant stanol ester in Benecol products are
additive to each other and thus using Benecol products can
be highly recommended also for patients using statins already.
Statins inhibit the synthesis of cholesterol in the liver, which
leads to higher uptake of LDL-cholesterol by an increased number of
LDL receptors. By comparison, plant stanols reduce the absorption of
cholesterol in the digestive tract. Thus combining products
enriched with plant stanols with statin therapy will deliver both
of these effects.
Adding Benecol products to
the diet of patients already on statin medication provides
additional 10-12% effect in LDL reduction , , . It means that a greater reduction of
cholesterol lowering can be achieved by combining Plant stanol
ester enriched Benecol products with statin treatment rather than
doubling the dose of statin, which generally produces only
additional effect of 6% , .
The additive cholesterol lowering effect of Plant stanol ester has
been shown to persist over time in patients on continuous statin